Programme
Please click here to download the final scientific programme
| Friday 11 April 2008 | ||
| OPENING ADDRESS |
08:15-08:30 | |
| P. Demoly, JC. Roujeau, DHM3 co-Presidents P. Scheinmann, SFAIC President R. Gerth van Wijk, EAACI President |
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| Plenary session 1 | 08:30 - 10:00 | |
| Epidemiology of hypersensitivity drug reactions RS Stern, USA |
08:30 | |
| The p/i concept dissected by a pharmacologist K Park, UK |
09:00 | |
| The limits in the clinical evaluation of drug hypersensitivity A Bircher, Switzerland |
09:30 | |
| Break and visit of the exhibition of the hosting CFA | 10:00 - 11:00 | |
| Plenary session 2 | 11:00 - 12:00 | |
| In vitro tests for drug allergy: are they really useful? W Pichler, Switzerland |
11:00 | |
| Does a DRESS syndrome exist? JC Roujeau, France |
11:30 | |
| Do we still need drug provocations? P Demoly, France |
12:00 | |
| Lunch break | 12:30-14:30 | |
| Plenary session 3 | 14:30 – 16:00 | |
| Virus reactivation and drug hypersensitivity syndrome risk factor K Hashimoto, Japan |
14:30 | |
| Drug hypersensitivity: predictive value of preclinical tests M Pallardy, France |
15:00 | |
| New drugs, new hypersensitivity reactions J Lübbe, Switzerland |
15:30 | |
| Break and visit of the exhibition of the hosting CFA | 16:00-16:30 | |
| Plenary session 4 | 16:30 – 18:00 | |
| What is new on the pharmacogenetics of drug hypersensitivity? M Pirmohamed, UK |
16:30 | |
| Recent advances on immunologic mechanisms of drug allergy JF Nicolas, France |
17:00 | |
| Effectiveness of tolerance induction to anti-cancer drugs M Castells, USA |
17:30 | |
| End | 18:00 | |
| Saturday 12 & Sunday 13 April 2008 |
Workshop
3 Practical Workshops related to drug hypersensitivity and covering the preliminary topic list listed below will be organised and chaired by specialists. These 120 minutes-workshops will be training sessions emphasizing on problem-solving, hands-on training and will require the involvement of the participants.
3 Advanced Workshops will aim at introducing scientists to new methodologies and latest tools used in the fields related to drug hypersensitivity. With a high teaching value, these 120-minutes sessions should also enhance the transfer of knowledge between academic and industrial fields. They may be accompanied by practical demonstrations.
Pre-registration is requested. Workshops have a limited number of seats
- Registration to 1 workshop : 100 euros
- Registration to 2 workshops : 150 euros
| Saturday 12 April 2008 (08:00-10:00) | |
Workshop 1 (Practical Workshop)
Objectives: This workshop will help attendees develop an understanding of the clinical approach to diagnosing the nature of an allergic drug reaction. Points to be covered will include the critical aspects of the patient’s history, the documentation of the drug exposure and the timing of events in relation to drug exposure. The immune mechanisms responsible for different clinical patterns clinical will be reviewed. The role of testing will be considered and put in place as a tool for making clinical decisions. The workshop will include a number of case examples and attendees are invited to submit interesting cases which will be used for discussion. Programme: Clinical patterns of drug hypersensitivity in relation to the underlying Immunological mechanisms General approach analysis of causality of drug hypersensitivity Approach to causality assessment in the individual patient Open discussion with example cases |
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Workshop 2 (Practical Workshop)
Objectives: Drug hypersensitivity reactions are mediated by specific immunological mechanisms. Various immunoassays can be used for the detection of drug-specific IgE mediated reactions. Detection of drug-specific T cell reactions is based on the proliferative capacity of lymphocytes and cytokine release (Th1/Th2) upon contact with the hapten. The session will address new developments of these methodologies with a focus on practical issues. |
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Workshop 3 (Advanced Workshop)
Objectives:
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| Sunday 13 April 2008 (08:00-10:00) | |
Workshop 4 (Practical Workshop)
Objectives: Coming soon |
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Workshop 5 (Advanced Workshop)
Objectives: Programme:
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Workshop 6 (Practical Workshop)
Objectives :
Programme:
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Symposia
Symposia are in-depth discussions covering the most important topics in the field of Drug Hypersensitivity. Speakers will present the very latest research results on fundamental and clinical issues in the field.
The four following themes have been selected by the Scientific Programme Committee: Immunology of drug hypersensitivity Pharmaco-epidemiology, phamacovigilance, Prediction and risk factors, Diagnosis and treatment
IMMUNOLOGY OF DRUG HYPERSENSITIVITY
Understanding the p-i concept
B. Gerber (Bern, Switzerland)
Update on T regulators: regulatory T cells in DIHS/DRESS and SJS/TEN
T. Shiohara (Tokyo, Japan)
PHARMACO-EPIDEMIOLOGY, PHARMACOVIGILANCE
Pharmacovigilant systems in the world : how accurate are they?
B. Bégaud (Bordeaux, France)
Nonclinical prediction of drug hypersensitivity reactions: what is missing? What could be done?
J. Descotes (Lyon, France)
PREDICTION AND RISK FACTORS
New findings in chemical allergens relevant to drug hypersensitivity
J-P. Lepoittevin (Strasbourg, France)
How predictive are animal models relevant to drug hypersensitivity
J. Uetrecht (Toronto, Canada)
DIAGNOSIS AND TREATMENT
Results from a large collaborative EU study on iodinated contrast media induced hypersensitivity
K. Brockow (München, Germany)
Biologicals : new challenges for drug hypersensitivity
N. Shear (Toronto, Canada)